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Metformin is a type 2 medication for diabetes that acts by activating AMPK, which changes downstream proteins and controls glucose and lipid metabolism (Yip et al

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This is mechanistically demonstrated in breast cancer models, where SFN, by activating the Nrf2 pathway, reduces the secretion of prostaglandin E2 (PGE2) from tumor cells, thereby triggering MDSCs to switch from an immunosuppressive to an immunogenic phenotype and inhibiting their expansion (76)

This is essential for preventing cell damage

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ME: Data curation, Investigation, Resources, Software, Validation, Visualization, Writing original draft, Writing review & editing