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In rats, counterclockwise hysteresis was observed between the plasma concentration of amphetamine and locomotor activity after administration of lisdexamfetamine, but no such hysteresis was observed after D-amphetamine administration (Rowley et al., 2012)

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Moreover, abnormality of the vessel wall is likely to result from increased synthesis of extracellular matrix (ECM) by intimal and adventitial fibroblasts

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