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They also confirmed that concurrent treatment with JHU083 and anti-PD-1 checkpoint inhibitor improved the antitumor effects compared with anti-PD-1 treatment alone, suggesting the presence of metabolic plasticity between cancer cells and effector T cells, which could be exploited as a metabolic checkpoint for cancer immunotherapy 200

Superoxide dismutases convert superoxide enzymatically into hydrogen peroxide, which can be converted into water either by the enzyme catalase or the enzyme glutathione peroxidase

5-Fluorouracil enhances the antitumor activity of the glutaminase inhibitor CB-839 against PIK3CA-mutant colorectal cancers

[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Li W., Yin L., Sun X., Wu J., Dong Z., Hu K., Sun A., Ge J

Focus on rare and aggressive cancers More studies are needed to explore rhamnetins efficacy in rare and aggressive cancers, such as pancreatic, ovarian, and gastric cancers, where existing treatments offer limited efficacy