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Econ Bot 40:137154

257 , E871E878 (1989)

Cholesterol is also enriched within the tumor tissue and excessive cholesterol accumulation directly drives CD8 T cell exhaustion [102]

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Together with the reported role of RRM1 knockdown in promoting ferroptosis through p53 ubiquitination and the p21-GPX4 signaling axis [48], these results strongly suggest that the tumor-killing ability of AAP NPs may be linked to the ferroptosis pathway