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Anti-Inflammatory and Anti-Fibrotic Effects Chronic low-grade perifollicular inflammation the kind that slowly scars follicle tissue without causing obvious redness or symptoms is increasingly recognized as a driver of hair miniaturization

Additionally, the increased MDA levels observed upon SYNCRIP depletion were significantly reduced following SYNCRIP restoration (Figure 3E-G), further linking SYNCRIP function to suppression of ferroptosis

It also helps in reversing the imbalance of matrix metalloproteinases (MMP-9) and their inhibitors (TIMP-1), and in preventing epithelial-mesenchymal transition (EMT) through the modulation of Nrf2, NF-B, and TGF-1/Smad2/3 signaling pathways 6

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The hair separates from the bottom of the follicle but remains firmly anchored in place