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One mechanism could be an ongoing acute phase response in the liver due to inflammatory signaling

doi: 10.1093/ndt/gfx304

Glutathione and Liver Health Glutathione is present in all mammalian tissues, but is most highly concentrated in the liver

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BSM Partners, which funded and conducted the work, provides formulation and consulting services to pet food companies including one or more brands that appeared on the FDAs most-reported list