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cyanocobalamin) ranged from 20 mcg to 1,840 mcg daily.(10,13) Methylcobalamin dosage was between 4 mg and 1,500 mg daily.(11,12) The duration of therapy in the four studies varied from 12 weeks(13) to 16 weeks(10,12) and 24 weeks.(11) In Fonseca et als study, compliance to therapy was checked through the measurement of changes in the serum level of vitamin B 12 as prescribed to the participants.(11) Farvid et al supplemented this with capsule counts and individual sessions with skilled counsellors, who promoted compliance to the intervention at regular intervals.(10) Two of the studies did not mention how compliance to therapy was ensured.(12,13) The main outcomes in the selected RCTs can be grouped into electrophysiological measures (namely VPTs and/or nerve conduction velocities) and neuropathic symptoms

doi: 10.1016/j.ccc.2022.07.007 [PubMed] 36333039 Coppler PJ, Elmer J

The vast majority of studies have been conducted in rodent models, and while these findings carry genuine scientific weight, the translation of animal research to human outcomes is never guaranteed