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In animal models, inhibition of TNF- has been shown to reduce liver steatosis and inflammation [190]

It has been reported that FOXO3 induces the activation of autophagy in neural stem cells (Audesse et al

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Beiboer et al

2AC), suggesting that Ubp2 removes the ubiquitin chain of uS10 in the free 40S and 80S ribosome, whereas Ubp3 trims the di-ubiquitin chain of uS10 in the free 40S and translating ribosome