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To complete the synthesis of (2 S ,3 R )- 34 first the iodomethyl group was transformed in two steps into the hydroxymethyl moiety, both hydroxy groups were silylated, the chiral auxiliary was removed and the amide nitrogen was protected as N- Boc to furnish (4 R ,5 R )- 47

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In comparison, the administration of letrozole loaded SLNs (5 mg/kg, 10 mg/kg) showed a shorter 108 3.42