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An efficient biological system (or a well-formulated supplement) uses the enzyme glutathione reductase to convert GSSG back into GSH, creating a continuous cycle of protection that maintains a healthy redox balance

If dryness becomes severe, with cracking, bleeding, or extreme discomfort, reduce application frequency

This issue requires further research in wildlife

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While topical application has minimal systemic absorption, the precautionary principle suggests avoiding use during pregnancy unless a healthcare provider approves