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Theranostics 11 , 22472262 (2021)

If cell division proceeds smoothly, the body can grow, regenerate, and replace damaged structures

Over-expressing anti-apoptotic Bcl2 factors has been shown to reduce HC death due to ototoxins (Cunningham et al., Purinergic Pathways Adenosine is an endogenous nucleoside present in all cells of the body that exerts its pharmacologic effects by activation of purine adenosine receptors, also present in the HCs, supporting Deiters cells and SGNs (Vlajkovic et al., 2007, 2009)

DOX mainly targets the heart, causing cardiotoxicity

Fibroblasts rush in and lay down collagen to close the gap, which can leave a patch that feels thick, tight, or ropey instead of smooth and flexible