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The K d values were determined using a nonlinear least-squares analysis and the equation: where [ L ] is the concentration of the histone peptide, [ P ] is the concentration of ZZZ3 ZZ domain, I is the observed change of signal intensity, and I max is the difference in signal intensity of the free and bound states of the ZZ domain

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Statements Data availability statement The original contributions presented in the study are included in the article/supplementary material

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However, when GSH-PEG liposomes were used to deliver an anti-amyloid single domain antibody fragment (VHH-pa2H) to the brain of mice, no increase in brain delivery was observed when compared with VHH-pa2H administered alone [48]