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TAOK2 deficiency caused dosage-dependent impairments in cognitive processes as well as abnormalities in neuronal structures and functions (Richter et al., 2019) and these changes were accompanied by reduced RhoA activity, and importantly pharmacological enhancement of RhoA activity restored abnormalities in neuronal structures (Richter et al., 2019)

Clin Cancer Res (2018) 24(5):1190201

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The toxicity profile included hypertension, gastrointestinal perforation, gastrointestinal bleeding, and thromboembolic events, and was not different from other bevacizumab-containing regimens