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and treat high-loading porous crystalline platforms as exploratory unless safety and stability are demonstrated early

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The continuous attenuation parameter (CAP) and liver stiffness measurement (LSM), assessed by vibration-controlled transient elastography (VCTE), were used as surrogates for steatosis and fibrosis respectively

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Instruments 1 H and 13 C NMR spectra were measured on a Bruker ARX 400 NMR spectrometer using CDCl 3 , DMSO- d 6 , or D 2 O as solvent and tetramethylsilane (TMS) as internal reference

Interestingly, Chac1 was downregulated across the entire disease spectrum, beginning in early MASLD and remaining suppressed through progression to MASH with advanced fibrosis (Figure 6D)