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Thus, when erythrocytes are exposed to high H 2 O 2 levels, organic peroxides will accumulate, since GPx and Prx2 become less efficient and CAT is not able to detoxify these organic peroxides [60]

While these approaches show promise in preclinical models, clinical translation faces substantial hurdles: most nanoparticles achieve only modest brain accumulation with heterogeneous parenchymal distribution, and their long-term safety, biodistribution, and immunogenicity remain poorly characterized (192)