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More serious but rare adverse events include pancreatitis, gallbladder problems, and changes in kidney function

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174 Interestingly, some emerging evidence suggests protein restriction may not be as important for patients being treated with RAAS inhibitors and SGLT2 inhibitors, and several leading guidelines do not recommend any protein restriction for people with CKD, although excess protein intake is often discouraged

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Forkhead box M1 (FOXM1) binds to the SIRT4 promoter to induce SIRT4 transcriptional activation, reduce the expression of pyroptosis-associated NLRP3 inflammasome and cleaved caspase 1, and increase the activity of HG-treated podocytes