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For instance, H4 lysine 12 lactylation (H4K12la) induces smooth muscle cell senescence by promoting the expression of aging-related genes, thereby accelerating atherosclerosis [20]

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Contamination with multiple heavy metals decreases microbial diversity and favors generalists as the keystones in microbial occurrence networks

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While effective in controlling disease activity, agents such as methotrexate and acitretin pose significant hepatotoxic risks

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