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Additionally, anti-nuclear IgG4 antibody significant titers have been detected in SLE patients, and it has been suggested that the effect of these antibodies on complement consumption and the production of proinflammatory cytokines may play a role in inhibiting the progression of SLE

doi: 10.1590/0001-3765201720160490 35 DangR.WangM.LiX.WangH.LiuL.WuQ.et al

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Similar patterns show up with glutathione, curcumin, and other notoriously hard-to-absorb nutrients

Nuttall et al.[37] studied the effect of chronic ingestion of therapeutic doses of APAP (1 gram, 4 times per day, for 2 weeks) on serum antioxidant capacity, and found a gradual and progressive decline to a level about 85% of control value