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Activation of angiotensin-converting enzyme 2/angiotensin (17)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling

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doi: 10.1055/s-2000-13206 110 ZhangQJiangYDengCWangJ

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The GAA repeat sequence has been reported to bind to splicing factors such as those in the serine/arginine (SR)-rich protein family, and the proteins heterogeneous nuclear ribonucleoprotein (hnRNP) A1 and hnRNP A2, thereby rendering them incapable of splicing the introns during RNA processing ( FXN transcript, hence affecting the expression of the frataxin protein

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