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and this suggest that normal wild-type mice have a better stress tolerance than BNDF heterozygous mice [86]

Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency

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Challenges and potential solutions Therapeutic trials studying the potential of activating ROS downstream signalling pathway(s) to boost mitophagy face some challenges (Table 2)

Ciliary neurotrophic factor cell-based delivery prevents synaptic impairment and improves memory in mouse models of Alzheimers disease