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The mediation models were used to systematically classify APOE -related proteins into two protein groups: proteins showing stronger evidence in upstream mediation pathways ( APOE protein AD/A) were defined as mediator proteins

Alam MM, Kishino A, Sung E, Sekine H, Abe T, Murakami S, et al

46 , W510W513 (2018)

Additionally, to evaluate the binding affinity of 2,4-D to estrogen and androgen receptors, we performed yeast estrogen screen (YES) and yeast androgen screen (YAS) assays using a genetically modified strain of Saccharomyces cerevisiae

Genes Cells 3 , 569573 (1998)

Yes, it is legalbut its not FDA-approved as a drug