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Briefly, the authors studied the GPx-like activity of ebselen under cell-free conditions using GSH-reduced nicotinamide adenine dinucleotide (NADH)-GR coupled assay

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doi: 10.1016/j.freeradbiomed.2016.01.029, 44 Van MalderenS.HehlM.VerstraelenS.BreugelmansR.OeltzschnerG.SwinnenS

When translating RCD-targeted therapies from experimental mouse models to clinical trials for IRI-AKI, there are several key considerations and challenges that need to be addressed: relevance of mouse models, dosing and pharmacokinetics, safety and toxicity, biomarkers and endpoint selection, patient heterogeneity, and regulatory approval

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