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Common ions, like zinc (Zn 2+ ), magnesium (Mg 2+ ), iron (Fe 2+ /Fe 3+ ) and copper (Cu 2+ ), are co-factors of a variety of enzymes which play an important role in stabilizing enzyme conformation, transferring electrons, and connecting enzymes and substrates in enzymatic reactions (Valdez et al., 2014)

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This work was partially supported by the National Natural Science Foundation (31770796 to Y.J., 81730099 to X.X.), the National Science and Technology Major Project (2018ZX09711002-002-002) to Y.J., the National Key R&D Programs of China (2018YFA0507002), the Shanghai Municipal Science and Technology Major Project (2019SHZDZX02), the CAS Strategic Priority Research Program (XDB37030103) to H.E.X., and the Shanghai Municipal Science and Technology Commission Grant (20S11903200) to X.X

This forceful change in metabolism could be due to the deficiency of succinyl-CoA, which is a consequence of VitB12 deficiency, although no substantial data exists (Figure 4B)

This prevents dangerous swings in acidity that damage metal components

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