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doi: 10.1016/j.neuropharm.2020.108235 56

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Symptomatology (i.e., paresthesia, spontaneous pain, tactile allodynia and mechanical and thermal hypo/hyperalgesia) may improve and resolve spontaneously, or culminate in total loss of sensation and ultimately in foot ulceration and amputation

Nrf2 plays a vital role in antioxidant defense, with studies showing that its activation safeguards retinal tissue in DR models (180)

Moving forward, the integration of cutting-edge technologies such as multi-omics approaches, advanced imaging techniques, and computational modeling will be pivotal in unraveling these complexities