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Many individuals taking tirzepatide for weight management may simultaneously use creatine to preserve or build lean muscle mass during caloric restrictiona reasonable approach given that GLP-1 receptor agonists can lead to loss of both fat and muscle tissue

Bcl-2/adenovirus E1B 19kD-interacting protein 3 -like proteins (BNIP3L), also known as NIX is an outer mitochondrial membrane protein equipped with an LIR near its N-terminus to perform Parkin-independent mitophagy 64,65