glutathione half life intravenous pharmacokinetics half-life human in plasma in humans: Mean concentration-time profile Pharmacokinetic half-life and pharmacodynamic half-life. – Glutathione in Cellular Redox Homeostasis:

Journal of Regenerative Medicine, 15 (4), 345-359

In addition, GSSG retained in mitochondria during oxidative stress can lead to the S-gluthionylation of target proteins with mitochondrial dysfunction (20, 21)

212 FBXO31 enhances cisplatin-induced ferroptosis in cholangiocarcinoma cells and stem cell-like cells, and the mechanism may be related to increased GPX4 ubiquitination and proteasome degradation, which could be reversed by GPX4 overexpression

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doi: 10.1007/s10620-020-06133-5