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J., Warren, Z., Williams, A

Investigating the response of the butyrate production potential to major fibers in dietary intervention studies

We hypothesize that the influence of SFN on the gut microbiota is at least partly related to the effects on their habitat, i.e., the gut such as (i) alleviation of oxidative stress and inflammation in the intestine, (ii) increase of the expression of tight junction proteins, preventing excessive intestinal permeability and invasion of luminal bacteria, and (iii) promotion of gut detoxification capability via increase of activity of phase II detoxification enzymes such as GSTs

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In addition, CTN induced ferroptosis of human liver cancer HepG2 cells by significantly enhancing ROS accumulation, reducing GSH level, and downregulating the xCT and GPX4 expression, which could be inhibited by ferrostatin-1 (Fer-1, ferroptosis inhibitor) (Liu JL

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