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Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice

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Children with IBD generally have insufficient fiber intake, and supplementation with fiber and probiotics can restore symbiotic bacteria abundance, enhance barrier function, and reduce inflammation [250, 251], Moreover, IL-10 knockout mice fed a low-fiber diet show mucosal layer degeneration and severe colitis, directly confirming that genetic background amplifies the dietary effects [252]

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The relative importance of the three enzymes appears to be related to the H 2 O 2 levels in the RBC [59]

In the context of early osteoarthritis, recent trials suggest that MACI may slow degenerative progression when applied to isolated focal areas, though longitudinal studies remain limited and are complicated by variable definitions of early OA across trials (Muthu et al., 2023)