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mRNA expression of ER decreased in the adipose tissue of obese women [70], and selective depletion of ER in adipocytes subsequently increased the adipocyte size and total adiposity in both sexes [71]

It simply means your body may benefit more from pre-methylated forms of folate and B12

Vitamin B12 Consumer (nih.gov) We are excited to offer you a preservative-free form of B12 at our clinic

Immune System Boost Essential for red blood cell formation and immune resilience

Those considering B12 injections for non-medical purposes should discuss the risk-benefit profile with a healthcare professional, as the potential harms may outweigh any perceived advantages in the absence of deficiency

However, a study found that taking 1,000 mcg of B12 by mouth or injecting the vitamin achieved similar results in treating the deficiencies