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Am J Psychiatry 159(4):663665 Scott F, Hampsey E, Gnanapragasam S et al (2022) Systematic review and meta-analysis of augmentation and combination treatments for early-stage treatment-resistant depression

Open 5 , e2144279 (2022)

Rosmarinic acid caused a significant reduction in MAP in normotensive guinea pigs

DHFR inhibitors: reading the past for discovering novel anticancer agents

Interestingly, when the size of the alkyl-amine chain at the 4-position is increased, the selectivity is compromised as a consequence of an increase of the cytotoxicity on macrophages, as can be seen in compounds 67 (SI = 8.2), 72 (SI = 13.1), 84 (SI = 16.5) and 88 (SI = 19.5)

However, the MN-CCPCA (S) and the MN-CCPCA (M) groups did not show tumor recurrence within 2 weeks and even displayed complete elimination of U87MG tumor (Fig