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Neuropsychiatric abnormalities Psychiatric problems are associated with B 12 deficiency in adults between the ages of 4090 years and rarely affect people of younger age (Stanger et al., 2003)

Furthermore, it has been observed that fumarate and succinate share a similar affinity for the succinate-binding site of succinate dehydrogenase (SDH)

80,114 Unmet Needs Malignancy Screening Although DM diagnosis typically triggers an extensive screening work-up to search for an underlying malignancy, a mortality benefit, which is the gold standard for supporting screening procedures, has never been demonstrated