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Treatment doses typically range from 50 to 150 g daily of cyanocobalamin, preferably taken between meals, or 1,000 g daily for more rapid repletion, continued until deficiency is corrected

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Patients with Leber's Disease: Vitamin B12 levels may exacerbate optic nerve atrophy

The degree of hypometabolism, meaning the brain's ability to generate energy from its primary energy substrate glucose, is already diminished by at least 50%

Urinary osmolality were measured by the 5,004 Micro-Osmette (Precision Systems)

In order to determine which isoform of Sec24 is involved in the sorting of SLC7A11, immunoprecipitation (IP) was carried out to test the interaction of SLC7A11 and Sec24 isoforms