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It should be mentioned that the present study is limited by the relatively small cohort size

A limitation of our study was the absence of muscle biopsy, which could have provided additional data regarding intramuscular LCR levels as well as molecular and cellular responses, including proteins involved in the mTOR pathway

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Furthermore, in line with the recent elucidation of the mechanism by which fumarate accumulation in these cells induces epithelial-to-mesenchymal-transition (EMT) 40 , the protein expression data showed a clear EMT signature exemplified by downregulation of E-cadherin ( Cdh1 ) and epithelial cell adhesion molecule ( Epcam ), as well as upregulation of vimentin ( Vim ) (Fig

Carbon dot superoxide dismutase nanozyme enhances reactive oxygen species scavenging in diabetic skin wound repair

All analysis is based on publicly available information