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Alternatively, our finding that diabetes duration independently predicts poorer spatial navigation performance suggests that the brain is impacted not only by acute glycaemic fluctuations but also by their cumulative effects over time

A randomised controlled trial is considered the gold standard of clinical evidence

Zhai FG, Liang QC, Wu YY, Liu JQ, Liu JW

It applies to clinical trials that use different extraction forms, for example, curcumin-containing substances with unspecified amounts of curcuminoids that prevent establishing the equivalency of doses or the minimum therapeutic threshold Large, more centralized, and strictly controlled clinical trials are required in the future to provide more scientific evidence to assess conferred benefit and a more secure way for adding these natural supplements to evidence-based treatment options for breast cancer

2014 Feb;13(1):8-12

These insights open new avenues for research into pathogenesis and the investigation of targeted approaches based on the modulation of proteasomal function