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2023 FDA Science Forum Protein immunogenicity: impact of aggregate morphology and innate immune response modulating impurities on local immune activation Authors: Center: Contributing OfficeCenter for Drug Evaluation and Research Abstract Immunogenicity has been shown to negatively impact safety, PK, and efficacy

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Glutathione reductase, mol product formed /min What conclusions can you draw from these results

A steady decrease follows, reaching typical adult concentrations by the late teens

Neuro Endocrinol Lett 2001;22:2514

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