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It has been reported in a number of studies that specific ABR genes are present in the gut microbiota of many individuals from different countries 15,16

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J Immunol 198(10):38093814

Cytokines such as IL-1 and TNF-, which are pivotal in inflammation, also serve as sleep-regulating molecules, promoting NREM sleep at physiological levels but contributing to sleep fragmentation when chronically elevated (Besedovsky et al., 2019