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(5) D A Sibarov, A B Volnova, D S Frolov, and A D Nozdrachev (2007) Effects of intranasal administration of epitalon on neuron activity in the rat neocortex Neuroscience and Behavioral Physiology, 2007 Nov, Volume 37 (Issue 9), Pages 889-93

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Standard protocols suggest a dose of 5 micrograms per kilogram of body weight to achieve therapeutic effects

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A shortfall in magnesium or B6 compromises monoamine neurotransmitter synthesis and leads to depression, a symptom shared by LC, POTS, ME/CFS, MCAS, and EDS