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Regarding cardiac risk, the lorcaserin group was non-inferior to the placebo group with slightly better values in cardiac risk factors (blood pressure, heart rate, glycemic control, lipid profile)

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Together, these findings demonstrate: (i) modulatory effects of CD38 mAbs on ADPR-Cyclase and cADPR-Hydrolase activities in the LP-1 line, and (ii) antibody-specific differences in regulating CD38 catalytic functions