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45 It appears that genotypic changes of these enzymes leads to potentially different risk/benefit ratios when APAP is ingested

During the last years, the utilization of patient stem cellbased high-throughput screening approaches and in silico prediction tools such as network mapping, genome-wide association studies, (GWAS) and rare variant association studies (RVAS) significantly accelerated the identification of candidate drugs for disease treatment

In humans, alterations in the normal functioning of these efflux pumps are implicated in the etiology of diseases such as DubinJohnson syndrome 7 and cystic fibrosis 8,9,10