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In sensible cosmetic concentrations this is not a general concern, but it argues against casual escalation of dose or concentration in the belief that more is better

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Regul Pept 181:5066 Bdis B, Kardi O, Nmeth P, Dohoczky C, Kolega M, Mzsik G (1997) Evidence for direct cellular protective effect of PL-10 substances (synthesized parts of body protection compound, BPC) and their specificity to gastric mucosal cells

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