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Basic Clin Pharmacol Toxicol 97:296301 Pato MT, Murphy DL, De Vane CL (1991) Sustained plasma concentrations of fluoxetine and/or norfluoxetine four and eight weeks after fluoxetine discontinuation

Endogenous neurotransmitter metabolism generates hydrogen peroxide Endogenous amine based neurotransmitter (e.g

The most representative example of such adducts is represented by the reaction of hydroxyl radicals with the DNA base Guanine, resulting in the formation of the 8-OH Guanine adduct (see Fig

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Dilda, Tumour Metabolism Group, Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology

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