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Journal of Hazardous Materials, 297 , 1724

In a recent study, capmatinib decreases APAP-induced elevation of TNF- as an important mechanism to limit liver injury, as exposure to exogenous recombinant TNF- increases APAP-induced serum ALT by more than 50%, whereas IL-1 or IL-6 increases ALT by only 20% [207]

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For the specific role and pathogenic mechanisms relating CP, HMGB1 and TF to PD, further exploration and verification are still required

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