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In humans, disruption of circadian rhythms due to shift work or sleep disorders are associated with a decreased glomerular filtration rate (GFR) (5), increased risk of chronic kidney disease (CKD) (6), polyuria, and nocturia (7)

Results can vary, but many individuals report seeing improvements in skin texture and appearance within 4 to 12 weeks of consistent use

Nature 367:645648 Bonnet D, Dick JE (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

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That said and I want to be clear about this this does not mean that fiber is bad or that a long-term zero fiber diet couldnt have negative consequences on the microbiome

Firstly, the packaging is functional