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In the realm of personalized medicine, a deeper understanding of disease mechanisms is poised to integrate biochemically cleavable conjugations into individualized treatment plans, enhancing therapeutic outcomes while minimizing adverse reactions

By combining HRMS with computational toxicology tools (e.g., Discovery Studio), researchers can perform preliminary toxicity risk assessments and predict potential toxic mechanisms through metabolic activation pathway analysis

Afterwards, the tumor lysates were collected by centrifugation at 8000 g for 10 min at 4 C after lysed with Frozen Type Tissuelyser

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Proc Natl Acad Sci U S A 103:72827287 McGarry JD, Brown NF (1997) The mitochondrial carnitine palmitoyltransferase system