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34 Fenton reaction and lipid peroxidation in hepatotoxicity According to a more recent review by Dixon and Stockwell, 35 there are three essential hallmarks that define ferroptosis: the loss of lipid peroxide repair capacity by the phospholipid hydroperoxidase GPx4, the availability of redox-active iron, and the oxidation of PUFA-containing phospholipids . Although the term ferroptosis is new, the process of iron-dependent lipid peroxidation (LPO) as a mechanism of cell death in the liver has been recognized for 60 years

The identification and counting of CK18 + CD45 CTCs, as well as the examination of SOX2 levels in CTCs, were conducted through IF staining using the following primary antibodies: anti-CD45 (1:200, 60287-1-Ig, Proteintech), CoraLite Plus 488-conjugated anti-CK18 (1:200, CL488-66187, Proteintech), and CoraLite Plus 647-conjugated anti-SOX2 (1:200, CL647-66411, Proteintech)

For example, sulfasalazine, a clinically used ferroptosis inducer, is very effective against thyroid cancer cells, indicating its possible use in TAO (367, 368)

This study was supported by grants to Szu-Tah Chen from the Chang Gung Memorial Hospital (CMRPG3H0411, CMRPG3H1261 and CMRPG3J1741) and a grant to Mei-Chich Hsu from the Ministry of Science and Technology of Taiwan (NSC101-2410-H-037-016-MY3)

5.3 Ginseng Ginseng refers to the dried root and rhizome of the Araliaceae plant ginseng

FOXK1 and FOXK2 were differentially phosphorylated in released and non-arrested cells (Fig