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In addition, miR-1294 suppressed targeting protein for Xenopus kinesin-like protein 2 in glioma cells leading to enhanced temozolomide activity [101]

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Tumor progression into soft tissues, lymph nodes or distant metastatic sites have been shown to dramatically reduce 5-year overall survival in patients with PTC, highlighting the need for a novel therapeutic approach for highly aggressive forms of PTC 6

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Further experiments demonstrated that glutathione peroxidase 3 (GPX3) significantly enhanced the phagocytic capacity of inducible bone marrow-derived macrophages (iBMDMs) and primary BAMs while reducing lipid peroxidation, suggesting that GPX3-mediated suppression of lipid peroxidation may be a key mechanism promoting phagocytosis

The lens has a protective role for the other eye structures also, because light and oxygen are synergistically involved in the pathogenesis of cataract