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Die Ergebnisse zeigten, dass GHK-Cu direkt an SIRT1 bindet und einen Protein-Komplex bildet, wobei die interagierenden Aminosaeurereste GLU-230 und ASN-226 identifiziert wurden Li et al., 2025

These metabolites, together with mitochondrial DNA released into the cytoplasm, activate the NLRP3 inflammasome and cGAS-STING pathways, driving the release of IL-1 and type I interferons

Homozygous (transfusion-dependent) thalassaemia Transfusion-dependent thalassaemia poses a significant burden to health services due to its life-long chronic nature and severity