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They are widely employed as vehicles for delivering a range of therapeutic agents such as antibodies, nucleic acids, chemotherapeutic drugs, etc

Andersson, U., and K.J

Evidence shows that MTHFR acts both as a modulator and a target of epigenetic regulation: Promoter DNA methylation, chromatin state and non-coding RNAs can alter its expression, while reduced MTHFR activity, whether genetic or epigenetic, reduces SAM levels, limiting methyltransferase capacity and favoring hypomethylation at methylation-sensitive loci

Recent pre-clinical metabolomic studies provide insight into future therapeutic targets for TDLN based interventions

Leuk Res 32(12):1895-1902, 2008

doi: 10.1016/j.jphs.2022.11.001 193