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Several factors, such as diet, microbial metabolism of tryptophan, and endogenous enzymatic activity, can provide critical signals to the host, aiding in resisting colonization and defending against mucosal inflammation [51]

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Am J Pathol 56:111128 Miao L, Deng G-X, Yin R-X, Nie R-J, Yang S, Wang Y, Li H (2021) No causal effects of plasma homocysteine levels on the risk of coronary heart disease or acute myocardial infarction: A Mendelian randomization study

226,227 The level of DNA methylation in the body has the characteristics of an epigenetic clock, which shows that the overall level of epigenetic modifications in the body decreases with age

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10.1016/j.neuron.2019.02.008 Neuron 79 FulopT.WitkowskiJ