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Intramuscular replacement therapy is indicated for patients with: Significant B12 deficiency (thresholds depend on local laboratory reference ranges) Neurological symptoms or signs Pernicious anaemia Malabsorption syndromes The standard UK regimen for patients without neurological involvement involves hydroxocobalamin 1mg intramuscularly three times weekly for two weeks, followed by maintenance injections every 2-3 months (often 3-monthly)

Author contributions PD and FS conceived and designed the experiments

Chem Biodivers 2021;18(3):e2000812

This phase is critical for DNA damage repair, immune memory and homeostasis, synaptic downscaling, and clearance of debris and metabolic waste including byproducts of oxidative stress from brain tissue (Tononi and Cirelli, 2006

The number of patients with liver cirrhosis was higher in patients treated without AZT (36.0% vs